According to research in JAMA Network Open, taking hypertension medication in the evening is more effective than in the morning.
Scientists from China (Sichuan University) have found that taking blood pressure medication before bed is more effective than taking it in the morning. Their publication in JAMA Network Open demonstrates that evening intake improves both daytime and nighttime pressure control without increasing the risk of side effects.
In a controlled randomized study, 720 individuals with hypertension received a standard combination of olmesartan and amlodipine either in the morning (6 AM to 10 AM) or in the evening (6 PM to 10 PM). After 12 weeks, those who took the medication at night showed a more significant reduction in nighttime pressure: systolic pressure dropped 3 mmHg more, and diastolic pressure dropped 1.4 mmHg more.
Furthermore, 79% of participants in the “evening” group reached target nighttime pressure values compared to 70% in the “morning” group. Daytime pressure control was also better: 89% of the evening group versus 82% of the morning group reached normal levels. Morning pressure readings decreased more effectively with evening intake, and dosage increases were less frequently needed.
The study authors emphasize that taking medication in the evening is not only safe but can also become an important tool in managing difficult-to-control hypertension, especially for patients with nocturnal pressure spikes.
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